Broadly speaking, uveitis is inflammation affecting the uveal tract, although management and prognosis for vision loss differs significantly according to what part of the eye is affected (i.e., anterior, posterior, intermediate, or panuveitis). Thus, prompt identification and localizing of inflammation is critically important, even though early indicators of active disease are often subtle and may not be apparent on clinical examination or on imaging.
For patients with uveitis and suspected retinal involvement, results from a flicker electroretinogram (flicker ERG) are extremely useful for making a diagnosis and monitoring disease activity. Clinicians can identify retinal dysfunction early then see functional improvement on the flicker ERG after the introduction of anti-inflammatory treatment with steroids or immunomodulatory therapy. An improvement in retinal function can indicate the plausibility of tapering the drug dosage.